全文获取类型
收费全文 | 27833篇 |
免费 | 3764篇 |
国内免费 | 719篇 |
专业分类
耳鼻咽喉 | 435篇 |
儿科学 | 749篇 |
妇产科学 | 372篇 |
基础医学 | 1872篇 |
口腔科学 | 1745篇 |
临床医学 | 1530篇 |
内科学 | 4137篇 |
皮肤病学 | 309篇 |
神经病学 | 889篇 |
特种医学 | 783篇 |
外国民族医学 | 18篇 |
外科学 | 8428篇 |
综合类 | 2345篇 |
现状与发展 | 5篇 |
预防医学 | 1063篇 |
眼科学 | 411篇 |
药学 | 761篇 |
8篇 | |
中国医学 | 250篇 |
肿瘤学 | 6206篇 |
出版年
2024年 | 13篇 |
2023年 | 716篇 |
2022年 | 688篇 |
2021年 | 1433篇 |
2020年 | 1511篇 |
2019年 | 1550篇 |
2018年 | 1493篇 |
2017年 | 1366篇 |
2016年 | 1285篇 |
2015年 | 1424篇 |
2014年 | 2110篇 |
2013年 | 2113篇 |
2012年 | 1456篇 |
2011年 | 1577篇 |
2010年 | 1158篇 |
2009年 | 1230篇 |
2008年 | 1370篇 |
2007年 | 1217篇 |
2006年 | 1095篇 |
2005年 | 1005篇 |
2004年 | 926篇 |
2003年 | 797篇 |
2002年 | 647篇 |
2001年 | 545篇 |
2000年 | 446篇 |
1999年 | 402篇 |
1998年 | 345篇 |
1997年 | 298篇 |
1996年 | 237篇 |
1995年 | 217篇 |
1994年 | 216篇 |
1993年 | 153篇 |
1992年 | 164篇 |
1991年 | 147篇 |
1990年 | 121篇 |
1989年 | 109篇 |
1988年 | 99篇 |
1987年 | 79篇 |
1986年 | 82篇 |
1985年 | 77篇 |
1984年 | 67篇 |
1983年 | 49篇 |
1982年 | 56篇 |
1981年 | 46篇 |
1980年 | 49篇 |
1979年 | 38篇 |
1978年 | 32篇 |
1977年 | 19篇 |
1976年 | 19篇 |
1975年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 343 毫秒
991.
992.
Yue-Chao Ding Wei Yu Chao Ma Qian Wang Chang-Shan Huang Tao Huang 《International journal of clinical and experimental pathology》2014,7(11):8065-8070
Introduction: Dysregulation of long non-coding RNAs (lncRNAs) plays critical roles in tumor progression. lncRNA LOC285194 was previously shown to be correlated with aggressive clinicopathological features and poor prognosis in several cancers. The aim of this study was to investigate relationship between LOC285194 expression and clinical outcomes in human pancreatic ductal adenocarcinoma (PDAC). Methods: Quantitative real-time PCR (qRT-PCR) assay was performed to detect the expression of lncRNA LOC285194 in human PDAC cells and tissue samples. The association of LOC285194 expression with clinicopathologic features was analyzed. Kaplan-Meier analyses were used to assess survival of patients. Univariate and multivariate analyses were performed using the Cox proportional hazards model to analyze the prognostic significance of LOC285194 expression. Results: Our data showed that the relative level of LOC285194 in PDAC cells was significantly lower than that in normal human pancreatic duct epithelial cell line. Also, the expression of LOC285194 in PDAC tissues was significantly lower than that in adjacent non-tumor tissues. By statistical analyses, low LOC285194 expression was observed to be closely correlated with clinical stage, lymphnode metastasis and liver metastasis. Kaplan-Meier survival analysis revealed that patients with low LOC285194 expression had a poor overall survival compared with the high LOC285194 group (P < 0.05). Univariate and multivariate analyses showed that low LOC285194 expression was an independent poor prognostic factor for PDAC patients. Conclusions: Our data provided the first evidence that reduced LOC285194 in PDAC tissues was correlated with tumor progression, and lncRNA LOC285194 might be a potential molecular biomarker for predicting the prognosis of patients. 相似文献
993.
994.
995.
The purpose of this study was to evaluate the results of our correction osteotomies of distal radial malunions without a bone graft. Eleven consecutive patients (mean age 52 years, range 18–71) were treated. A dorsal approach was utilised to perform an opening-wedge osteotomy which then was stabilised with two dorsal columnar plates without filling the osteotomy gap. All patients went on to radiographic union with a filling of the osteotomy gap within a mean period of 3 months (range 2–6 months). All patients had satisfactory results in terms of function and pain. Correction osteotomy and stabilisation with bicolumnar locked plate fixation without a bone graft provides sufficient stability to allow the highly vascularised metaphysis to heal. In patients without risk factors predisposing to non-union, this procedure is safe and feasible. 相似文献
996.
997.
目的 了解生活在社区的恢复期精神疾病患者在疾病康复过程中的生存压力。方法 2017年8月至2018年1月,选取北京市某社区15例恢复期精神疾病患者,通过半结构式访谈的方式收集资料,以Colaizzi 7步分析法分析资料。结果 得出4个主题:精神疾病症状和药物不良反应等引起的生理性压力;因疾病转归和日常生活角色冲突产生的精神心理性压力;社会歧视、缺乏工作机会和难以获取社会福利资源等带来的社会环境压力;贬低歧视和家庭亲属关系恶化导致的人际交往压力。结论 恢复期精神疾病患者重返家庭和社会后存在明显的生存压力,压力源包括疾病症状、社会歧视、人际关系等多个方面,因此,应注重消除精神疾病患者的自我歧视,完善社会支持与社会福利体系,增加个性化的社区精神康复活动,以减轻患者生存压力,促进其康复。 相似文献
998.
999.
1000.
《Surgery (Oxford)》2020,38(7):411-417
Intestinal and multivisceral transplantation can be a lifesaving treatment for patients with complications from the treatment of intestinal failure. However, the indications for this highly specialized treatment are broadening and include other such indications as patients with acute abdominal vascular catastrophes as well as patients with previously unresectable benign intra-abdominal tumours. Since the first successful multivisceral transplant in the late 1980s, the field has expanded and more than 4000 transplants have taken place worldwide and outcomes continue to improve. However, complications are still commonplace and multivisceral and intestinal transplant recipients are more likely to suffer from the complications of transplantation than any other solid organ transplant group. The most important complications are rejection and sepsis, with sepsis remaining the leading cause of death in this patient group. That said the outcomes for intestine alone transplants have improved to such a degree that they are close to that of intestinal failure patients on long-term parenteral nutrition and therefore we may be entering an era where intestinal transplantation will be offered as an alternative to parenteral nutrition for patients with intestinal failure. 相似文献